switches.ELM

Predicted switches in the ELMs Resource

General :Overview Visualisation Statistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificity Competition Domain hiding Motif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : Allostery Physicochemical compatibility Pre-translational Defined PTM-induced

Pre-assembly - Composite binding site formation

The formation of a complex results in the generation of a continuous motif-binding site that spans more than one component of this complex. Neither complex subunit on its own contains a functional binding domain for the motif, and interaction of the motif only occurs in the context of the active, fully assembled complex.

Accession	Protein	Gene	Motif	Start	Stop	Vis
P17495	Disintegrin trigramin-beta-2	None	LIG_RGD	51	53	view
P35555	Fibrillin-1	FBN1	LIG_Integrin_isoDGR_1	2304	2306	view
P49919	Cyclin-dependent kinase inhibitor 1C	Cdkn1c	LIG_SCF_Skp2-Cks1_1	338	345	view
P49918	Cyclin-dependent kinase inhibitor 1C	CDKN1C	LIG_SCF_Skp2-Cks1_1	306	313	view
P62384	Disintegrin albolabrin	None	LIG_RGD	51	53	view
P21404	Genome polyprotein	None	LIG_RGD	858	860	view
P04004	Vitronectin	VTN	LIG_RGD	64	66	view
P21815	Bone sialoprotein 2	IBSP	LIG_RGD	286	288	view
P02887	Discoidin-1 subunit B/C	dscC-1	LIG_RGD	79	81	view
P03305	Genome polyprotein	None	LIG_RGD	869	871	view
P31096	Osteopontin	SPP1	LIG_RGD	152	154	view
P02751	Fibronectin	FN1	LIG_RGD	1524	1526	view
P02751	Fibronectin	FN1	LIG_Integrin_isoDGR_1	263	265	view
P02751	Fibronectin	FN1	LIG_Integrin_isoDGR_1	367	369	view
P02751	Fibronectin	FN1	LIG_Integrin_isoDGR_1	501	503	view
P02751	Fibronectin	FN1	LIG_Integrin_isoDGR_1	1432	1434	view
Q66578	Genome polyprotein	None	LIG_RGD	764	766	view
P29788	Vitronectin	Vtn	LIG_RGD	64	66	view
P04275	von Willebrand factor	VWF	LIG_RGD	698	700	view
P04275	von Willebrand factor	VWF	LIG_RGD	2507	2509	view
P46527	Cyclin-dependent kinase inhibitor 1B	CDKN1B	LIG_SCF_Skp2-Cks1_1	183	190	view
P10451	Osteopontin	SPP1	LIG_RGD	159	161	view
O43854	EGF-like repeat and discoidin I-like domain-containing protein 3	EDIL3	LIG_RGD	96	98	view
P13839	Bone sialoprotein 2	Ibsp	LIG_RGD	289	291	view
P17349	Zinc metalloproteinase/disintegrin	None	LIG_RGD	459	461	view
P03276	Penton protein	PIII	LIG_RGD	340	342	view
P11276	Fibronectin	Fn1	LIG_RGD	2181	2183	view
P11276	Fibronectin	Fn1	LIG_RGD	1614	1616	view
P11276	Fibronectin	Fn1	LIG_Integrin_isoDGR_1	264	266	view
P11276	Fibronectin	Fn1	LIG_Integrin_isoDGR_1	501	503	view
P08721	Osteopontin	Spp1	LIG_RGD	144	146	view